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4-(3-((4-Amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)methyl)phenyl)butan-2-one

4-(3-((4-Amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)methyl)phenyl)butan-2-one

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 Catalog Number NSJ-BC-007
Category TLR7/8 agonist
Sub-Category Vaccine adjuvants
Therapeutic applications Immune response modifier
CAS No. 2137880-92-1
Chemical Name 4-(3-((4-Amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)methyl)phenyl)butan-2-one
Chemical Formula C25H28N4O
Synonyms IMQ
Molecular Weight 400.53
Reference 1. Aichhorn, S, et al, A pH-sensitive Macromolecular Prodrug as TLR7/8 Targeting Immune Response Modifier Chem. Eur. J. 2017, 23, 17721-17726

2. Beesu, M, et al, Structure-based design of human TLR8-specific agonists with augmented potency and adjuvanticity, J. Med. Chem.  2015, 58, 7833–7849